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KMID : 1084220170240030127
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Journal of Rheumatic Diseases
2017 Volume.24 No. 3 p.127 ~ p.130
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Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms?
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Cacciapuoti Federico
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Abstract
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Hyperuricemia is related to metabolic syndrome, and is defined as an over-production or under-excretion of uric acid (UA), with increased UA serum concentration. Among other causes, Hyper-homocysteinemia (H-Hcy) can be responsible for hyperuricemia. The mechanisms underlying the association between these two conditions are unclear, but increased UA serum levels can be a consequence of renovascular atherosclerosis, with reduced UA excretion. An alternative hypothesis is the over-production of UA from adenosine (originating from S-adenosyl-homocysteine). Genetic polymorphism (C677T) of methylenetetrahydrofolate reductase (MTHFR) may contribute. A possible mechanism is purines biosyinthesis originating from this gene variant. However, the results obtained from several studies and meta-analyses of the relationship between H-Hcy and hyperuricemia are ambivalent, and broader research is needed.
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KEYWORD
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Uricemia, Uric acid, Homocysteine, MTHFR C677T polymorphism
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